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 | Dr. Vikash K. Yadav
Staff Scientist II, Chromatin Biology Lab
National Institute of Plant Genome Research (NIPGR), New Delhi
Tel: Phone: 91-11-26741612/14/17 Extn. 221
Direct: 91-1126735221
Email: vikash.yadav@nipgr.ac.in, yadav.vikash0301@gmail.com |
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 Professional & Academic Background: |
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Staff Scientist II (August 2023- Present): National Institute of Plant Genome Research, New Delhi. |
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DBT-Research Associate (March 2022-July 2023): School of Biological Sciences and Biotechnology, Goa University, India. |
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Post-Doctoral Fellow (October 2019- March 2021): Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Belgium. |
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Post-Doctoral Fellow (April 2017- July 2019): Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Sweden. |
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Ph.D (2010-2017): AcSIR, CSIR- National Botanical Research Institute, Lucknow, India |
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M.Sc. (2008-2010): in Marine Biotechnology, Department of Biotechnology, Goa University, India. |
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| Awards and Fellowships: |
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DBT-Research Associateship from the Department of Biotechnology, India (2022). |
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CSIR- Senior Research Associateship (SRA)/Scientists Pool Scheme fellowship (2023), Not availed |
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ARS-NET -2015 by Agricultural Scientists Recruitment Board |
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Junior Research Fellowship and Lectureship in National Eligibility Test (NET) (2010) in Life Sciences, India. |
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Graduate Aptitude Test in Engineering (GATE), (2010) in Life Sciences, India. |
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Recipient of studentship from the Department of Biotechnology, Govt. of India, during master's (2008-2010). |
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| Research Area: |
| Chromatin Biology, Epigenetics & Transcription Regulation |
| Research Interests: : |
| Role of higher-order chromatin organization in seed biology. |
Seeds constitute a significant part of our diet; however, our understanding of the molecular mechanisms underlying seed biology remains limited, thereby affecting the foundation of seed yield in agriculture. Thus, investigating the molecular mechanisms that regulate seed development presents an exciting research avenue with immense relevance for enhancing agricultural productivity.
To comprehensively comprehend seed biology, I am keen on exploring epigenetic approaches to identify enhancers elements using techniques such as Chromosome Conformation Capture (3C) based methods, ChIP-Seq, BS-Seq, RNA-Seq and Computational data analysis. These methods can help identify enhancer-like elements that govern the expression of genes associated with seed vigour. These enhancers represent potential targets for engineering agronomic traits and will open exciting avenues to develop climate-ready crops toward global food security.
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| Dissecting cell heterogeneity in the context of the epigenomics landscape |
Multicellular organisms harbor nearly identical genomes, yet distinct cells within these organisms perform specialized functions primarily due to their diverse epigenomes. Consequently, characterizing individual cell genomes holds immense significance, considering each cell encounters diverse physiological, environmental, and developmental cues. Single-cell sequencing technology, renowned for its unmatched resolution, has emerged as a potent tool for unraveling cellular heterogeneity.
Generating plant cell atlases based on epigenomic and transcriptomic data from diverse single-cell and developmental stages could serve as a valuable resource for comprehending gene function at the single-cell level. This approach could potentially address pivotal biological questions that traditional technologies relying on complex multicellular tissues cannot adequately answer.
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| Group Members |
| Rinchuila Shimphrui | Project JRF |
| Anushka Chaturvedi | Project JRF |
| ATHIRA PRASAD | Ph.D. Student |
| Sarvanand Singh | Ph.D. Student |
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| Interested in joining the lab?: |
| Motivated researchers (Postdoc/Ph.D./Trainee) interested in Plant epigenomics and transcription regulation are welcome to contact the PI. |
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Publications |
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Brahmam GS, Mishra D, Yadav VK* (2024). ReDtool: a Python-based command line tool for restriction digestion analysis of large DNA sequences. Journal of Plant Biochemistry and Biotechnology. 24:1-4. https://doi.org/10.1038/s41598-023-42420-7 |
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Yadav VK*, Jalmi SK, Tiwari S, Kerkar SK. (2023). Deciphering shared attributes of plant long non-coding RNAs through a comparative computational approach. Scientific Reports, 13, 15101. https://doi.org/10.1038/s41598-023-42420-7 |
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Yadav VK* Sawant SV, Yadav A, Jalmi SK, Kerkar SK (2022). Genome-wide analysis of long non-coding RNAs under diel light exhibits role in floral development and the circadian clock in Arabidopsis thaliana. International Journal of Biological Macromolecules, 223, 1693-1704. |
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Yadav, V.K., Singh, S., Yadav A., Agarwal, N., Singh B., Jalmi, S.K., Yadav, V.K., Tiwari, V.K., Kumar, V., Singh, R and Sawant, S.V. (2021). Stress conditions modulate the chromatin interactions network in Arabidopsis. Frontiers in Genetics, 12:799805. doi: 10.3389/fgene.2021.799805. |
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Yadav, V.K., Santos-Gonzalez, J. and Kohler, C. (2021). INT-Hi-C reveals distinct chromatin architecture in endosperm and leaf tissues of Arabidopsis. Nucleic Acids Research, 49(8), 4371-4385. |
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Yadav V.K. and Claeys Bouuaert C. (2021). Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae. Frontiers in Cell and Developmental Biology, 9:642737. doi: 10.3389/fcell.2021.642737. |
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Moreno-Romero, J., De Leon, G. D. T., Yadav, V. K., Santos-Gonzalez, J., & Kohler, C. (2019). Epigenetic signatures associated with imprinted paternally-expressed genes in the Arabidopsis endosperm. Genome Biology, 20(1), p.41. |
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Yadav, V. K., Yadav, V. K., Pant, P., Singh, S. P., Maurya, R., Sable, A., & Sawant, S. V. (2017). GhMYB1 regulates SCW stage-specific expression of the GhGDSL promoter in the fibres of Gossypium hirsutum L. Plant Biotechnology Journal, 15(9), 1163-1174. |
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Sable, A., Rai, K. M., Choudhary, A., Yadav, V. K., Agarwal, S. K., & Sawant, S. V. (2018). Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development. Scientific Reports, 8(1), 3620. |
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Dixit, G., Praveen, A., Tripathi, T., Yadav, V. K., & Verma, P. C. (2017). Herbivore-responsive cotton phenolics and their impact on insect performance and biochemistry. Journal of Asia-Pacific Entomology, 20(2), 341-351. |
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Singh, N., Kumar, R., Kumar, S., Singh, P. K., Yadav, V. K., Ranade, S. A., & Yadav, H. K. (2017). Genetic diversity, population structure and association analysis in linseed (Linum usitatissimum L.). Physiology and Molecular Biology of Plants, 23(1), 207-219. |
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Yadav, V.K., Rai, K.M., Yadav, V.K. and Sable, A. (2016). An overview of transcription regulatory elements in plant. Journal of Biological Sciences and Medicine, 2(4), pp.13-23. |
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Yadav, V.K. and Yadav, V.K. (2017). Impact of different carbon supplement on extraction of c-phycocyanin (C-PC) followed by poly-β-hydroxybutyrate (PHB) fromNostoc muscorum. International Journal of Pharmaceutical Sciences and Research, 620, p.A280. |
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