Of the diverse abiotic stresses, drought, salinity, and high temperature-stress contributes extensively to the yield reduction in agronomically valued crops. This urged us to decipher the molecular mechanisms involved in naturally abiotic stress-tolerant plants thus, we selected foxtail millet as our experimental model. In this context, we have examined the change in transcript profiles of foxtail millet at different time points of heat, dehydration, and salinity stress and identified a distinct set of genes in response to these stresses. Till date we have characterized the SiNAC, SiMYB, SiC2H2-type zinc fingers, SiAP2/ERF, SiWRKY, SiDof and SiHD-Zip transcription factor superfamily along with other classes of abiotic stress-related signalling molecules including SiALDH, SiWD40, Dicer-Like, Argonaute & RNA-Dependent RNA Polymerase, Si14-3-3, secondary cell wall synthesis-related gene family, SiARFs, SiHSP, SiSET, Aquaporins and C4-photosynthetic pathway associated gene families. Our ultimate aim is to utilize these genomic resources for improvement of highly consumed staple crops like rice through genetic engineering to design climate-smart future crops.