ABOUT THE NEXCADE PROGRAM AND SERVER

NEXCADE is a computational program that has been developed in the area of network perturbation analysis, based on an in-depth understanding of a large number of ecological, metabolic and gene regulatory networks and their responses to various kinds of perturbations. The program, originally written as a stand-alone unix code, has been converted into an automated online server with the same name in order to be more useful for the scientific community.

NEXCADE enables users to :
(a) Induce targetted disturbances into complex systems defined by networks, and
(b) Visualize and Analyse the consequences of perturbations focusing on the changes in topology and connectivity of the network as a function of the disturbance.

NEXCADE uses a graph theoretical approach to simulate perturbations in a user-defined manner, singly, in clusters or sequentially, and the outcomes, therefore, may vary depending upon the system or matrix in consideration.
For instance, Systemic damage would be 'useful' to a Biochemist interested in identifying drug targets, one or more nodes whose destruction would inhibit an entire pathway. The same node could be critical as a 'risk-area' for a Banker interested in identifying threats to a financial network.

The NEXCADE WebServer is divided into two major parts:

Note: If you are new to NEXCADE, we recommend using the BROWSE WEBS section first, that enables exploration of different aspects of the server.

FOR A STEPWISE TUTORIAL ON YOUR OWN DATA, PLEASE CLICK HERE

FOR A STEPWISE GUIDE TO BROWSING NETWORKS, PLEASE CLICK HERE