National Institute of Plant Genome Research
Digital India     
 
    Dr. Ashverya Laxmi
    Staff Scientist V
    Tel: 91-11-26741612,14,17 Ext. - 180
    Direct - 26735180
    Fax: 91-11-26741658
    E-mail: ashverya_laxmi@nipgr.ac.in, laxmiashverya@rediffmail.com
 Awards & Fellowships
Fellow, The National Academy of Sciences (NASI), India (2016)
National Women Bioscientist Award 2015 (Young category, Department of Biotechnology)
 Career
2018-till date   Staff Scientist V, National Institute for Plant Genome Research
2014-2018 - Staff Scientist IV, National Institute for Plant Genome Research
2010-2014 - Staff Scientist III, National Institute for Plant Genome Research
2006-2010 - Staff Scientist II, National Institute for Plant Genome Research
2005-2006 Post Doctoral Fellow, Samuel Robert Noble Foundation, Oklahoma, USA
2004-2005 Research Scientist, Centre of Plant Molecular Biology, University of Delhi
2003-2004 Post Doctoral Fellow, Ohio State University, Ohio, USA
2002-2003 SRF, Department of Plant Molecular Biology, University of Delhi
1997-2002 Ph.D. in Plant Molecular Biology from the Department of Plant Molecular Biology, University of Delhi
 Research Interests
Plants being sessile have developed a sophisticated machinery to perceive and respond to continuously changing environmental conditions. The exogenous signal is perceived either via membrane bound receptors, cytosolic receptors or receptors associated with different intracellular organelles. After the perception of the signal, a cascade of events starts which transduce it to the plant gene machinery to modulate gene expression and in turn plant development. These signaling cascades may involve different events such as changed ca2+ ion homeostasis, phosphorylation/dephsphorylation reactions, protein-protein interactions and so on. Earlier, this whole cascade was believed to be linear i.e. one signal evoking only one signaling pathway but with the plethora of reports pouring in, it is becoming increasingly clear that all these signaling pathways interact with each other and rather than being linear they are intermingled and are part of a web. Broadly speaking, one stimulus rather than evoking one signaling event can interact with several other signaling pathways so as to optimally modulate plant growth and development. These signaling interactions can happen at any level i.e. sharing of signaling components by multiple pathways, or convergence of signaling pathways at the level of transcription factors or further downstream at the promoter of the affected gene itself. There are several reports existing in plants, where light, hormone, sugar and stress signaling pathways have been shown to be interacting. Our group at NIPGR has been involved in characterizing these molecular interactions using Arabidopsis thaliana as a modal plant. The information generated would be employed for improving agronomically important traits in crop plants.
 Group Members
 Former Group Members
 
 Selected Publications
Jamsheer KM, Shukla BN, Jindal S, Gopan N, Mannully CT and Laxmi A (2018) The FCS-like zinc finger scaffold of the kinase SnRK1 is formed by the coordinated actions of the FLZ domain and intrinsically disordered regions. J Biol Chem. RA118.002073 (in Press)
Jamsheer KM, Sharma M, Singh D, Mannully CT, Jindal S, Shukla BN, Laxmi A (2018) FCS-Like Zinc Finger 6 and 10 repress SnRK1 signalling in Arabidopsis. Plant J. 94: 232-245.
Singh M, Gupta A, Singh A, Khurana JP and Laxmi A (2017) Arabidopsis RSS1 mediates cross- talk between glucose and light signaling during hypocotyl elongation growth. Scientific Reports 7: 16101.
Gupta A, Singh M, Laxmi A (2015a) Multiple interactions between glucose and brassinosteroid signal transduction pathway in Arabidopsis are uncovered by whole-genome transcriptional profiling. Plant Physiol. 168(3): 1091–1105.
Gupta A, Singh M, Laxmi A (2015b) Interaction between glucose and brassinosteroid during the regulation of lateral root development in Arabidopsis. Plant Physiol. 168(1): 307–320.
Singh M, Gupta A, Laxmi A (2014) Glucose control of root growth direction in Arabidopsis thalianaJ. Exp. Bot. 65(12): 2981-2993.
Kushwah S, Laxmi A (2014) The interaction between glucose and cytokinin signal transduction pathway in Arabidopsis thaliana. Plant Cell Environ. 37(1): 235-53.
Gupta A, Singh M, Jones AM, Laxmi A (2012) Hypocotyl directional growth in Arabidopsis: A complex trait. Plant Physiol. 159(4): 1463–1476.
Kushwah S, Jones AM, Laxmi A (2011) Cytokinin interplay with ethylene, auxin and glucose signaling controls Arabidopsis seedling root directional growth. Plant Physiol. 156(4): 1851–1866.
Murray JD, Muni RR, Torres-Jerez I, Tang Y, Allen S, Andriankaia M, Li G, Laxmi A, Cheng X, Wen J, Vaughan D, Schultze M, Sun J, Chamentier M, Oldroyd D, Tadege M, Ratet P, Mysore KS, Chen R, Udvardi MK (2011) Vapyrin, a gene essential for intracellular progression of arbuscular mycorrhizal symbiosis, is also essential for infection by rhizobia in the nodule symbiosis of Medicago truncatula. Plant J. 65(2): 244-52.
Tripathi V, Parasuraman B, Laxmi A and Chattopadhyay D (2009) CIPK6, a CBL-interacting protein kinase is required for development and salt tolerance in plant.  Plant J. 58: 778-90.
Laxmi A, Paul LK, Chaudhuri AR, Peters JL and Khurana JP (2006) Arabidopsis cytokinin resistant mutant, cnr1, displays altered auxin response and sugar sensitivity. Plant Mol. Biol. 62: 409-425.
Laxmi A, Paul LK, Peters JL and Khurana JP (2004) Arabidopsis constitutive photomorphogenic mutant bls1, displays altered brassinosteroid response and sugar sensitivity. Plant Mol. Biol. 56: 185-201.
Price J, Laxmi A, St. Martin SK, and Jang JC (2004) Global transcription profiling reveals multiple sugar signalling mechanisms in Arabidopsis. Plant Cell 16(8): 2128–2150.
 Other Research Publications
Mishra BS, Jamsheer KM, Singh D, Sharma M and Laxmi A (2017) Genome-wide identification and expression, protein–protein interaction and evolutionary analysis of the seed plant-specific big grain and big grain like gene family. Front. Plant Sci. 8:1812.
Kushwah S, Laxmi A (2017) The interaction between glucose and cytokinin signaling in controlling Arabidopsis seedling root growth and development. Plant Signal. Behav. 12(5):e1312241.
Jamsheer KM, Laxmi A (2015) Expression of Arabidopsis FCS-Like Zinc Finger genes is differentially regulated by sugars, cellular energy level, and abiotic stress. Front. Plant Sci. 6: 746.
Jamsheer  KM, Mannully CT, Gopan N, Laxmi A (2015) Comprehensive evolutionary and expression analysis of FCS-Like Zinc Finger gene family yields insights into their origin, expansion and divergence. PLoS ONE 10(8): e0134328.
Singh M, Gupta A, Laxmi A (2015) Ethylene acts as a negative regulator of glucose induced lateral root emergence in Arabidopsis. Plant Signal. Behav. 10(9): e1058460.
Singh M, Gupta A, Laxmi A (2014) Glucose and phytohormone interplay in controlling root directional growth in Arabidopsis. Plant Signal. Behav. 9: e29219.
Jamsheer KM, Laxmi A (2014) Domain of unknown function 581 is plant specific FCS-Like Zinc Finger involved in protein-protein interaction. PLoS ONE 9(6): e99074.
Kushwah S, Jones AM, Laxmi A (2011) Cytokinin-induced root growth involves actin filament reorganization. Plant Signal. Behav. 6: 11, 1848-1850.
Gupta A, Singh M, Mishra BS, Kushwah S, Laxmi A (2009) Role of glucose in spatial distribution of auxin regulated genes. Plant Signal. Behav. 4(9): 862–863.
Tripathi V, Syed N, Laxmi A, Chattopadhyay D (2009) Role of CIPK6 in root growth and auxin transport. Plant Signal. Behav. 4(7): 663–665.
Mishra BS, Singh M, Aggrawal P and Laxmi A (2009) Glucose and auxin signaling interaction in controlling Arabidopsis thaliana seedlings root growth and development. PLoS ONE 4(2): e4502.
Laxmi A, Pan J, Morsy M and Chen R (2008) Light plays an essential role in intracellular distribution of auxin efflux carrier PIN2 in Arabidopsis thaliana. PLoS ONE 3(1): e1510.
Khurana JP, Dasgupta U, Laxmi A, Kumar D and Paul LK (2004) Light control of plant development by phytochromes: A Perspective. Proc. Indian Natl. Sci. Acad. B70: 379-411.
 Reviews and Book chapters
Singh M, Gupta A, Singh A and Laxmi A (2017) Striking the right chord: signaling enigma during root gravitropism. Front. Plant Sci. 8:1304.
Sharma M, Laxmi A (2016) Jasmonates: emerging players in controlling temperature stress tolerance. Front. Plant Sci. 6: 1129.
Singh D, Laxmi A (2015) Transcriptional regulation of drought response: A Tortuous network of transcriptional factors. Front. Plant Sci. 6: 895.
Singh M, Gupta A, Laxmi A (2015) Glucose and brassinosteroid signaling network in controlling plant growth and development under different environmental conditions. In Mechanism of Plant Hormone Signaling under Stress, eds Giridhar Pandey, publisher Wiley, in press.
Laxmi A, Gupta A, Mishra BS, Singh M, Jamsheer KM, Kushwah S (2013) Signal integration, auxin homeostasis, and plant development. In R. Chen and F. Baluska, eds, Polar Auxin Transport, Signaling and Communication in Plants, 17, Springer-Verlag Berlin Heidelberg, pp 45-79.
Khurana JP, Tyagi AK, Khurana P, Kochhar A, Jain PK, Raychaudhuri A, Chawla R, Bharti AK, Laxmi A and Dasgupta U (1999) Molecular genetic analysis of constitutively photomorphogenic mutants of Arabidopsis in: S.K. Sopory, S.C. Maheshwari and R. Oelmuller, (s), Signal transduction in plants - Current Advances, pp. 25-37. Kluwer Academic Publishers, New York.
Khurana JP, Dasgupta U, Laxmi A, Kumar D and Paul LK (2004) Light Control of Plant Development by Phytochromes: A Perspective. Proceedings Indian National Science Academy,B70: 379-411.